LSI unveils two centers
Director Alan Saltiel announced the establishment of
two new centers of collaboration within the multidisciplinary Life Sciences
Institute (LSI) May 14 during LSI’s Grand Opening Convocation.
“Our recruiting is going well, and now is the time to begin initiatives
that will really help to bring scientists together across scientific fields,” Saltiel
said. “These programs are at the forefront of scientific discovery and
will catalyze interactions across the campus.”
The Center for Chemical Genomics (CCG) will apply the latest high-throughput
laboratory technology to the search for small molecular tools that will help
researchers explore living cells.
These molecular tools will enable researchers to measure the cell’s dynamic
systems in action, relatively non-invasively. CCG tools may help discover how
cells communicate, how they turn genes on and off, how they release newly made
proteins, or send broken parts to the trash can.
The heart of CCG will be a robotic lab capable of screening tens of thousands
of candidate molecules for possible effects on cells. This will be a core collaboratory
for LSI scientists and other U-M researchers.
The center will be headed by David Sherman, the John Gideon Searle Professor
of Medicinal Chemistry in the Department of Medicinal Chemistry (College of
Pharmacy) and a research professor in LSI. Sherman’s research centers
on combing through naturally occurring chemicals from marine microorganisms
to find potential cancer and anti-infective drugs.
The Center for Structural Biology is a critical mass of leading researchers shedding
light on the very specific shapes and forms of molecules in the living cell and
studying how they interact with one another in health and disease.
The collaboratory is centered around a protein production facility and an x-ray
crystallography suite. This facility also serves as a core laboratory for all
U-M researchers interested in understanding the three-dimensional structure of
Four new LSI faculty bring total to 13>