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LSI unveils two centers


Director Alan Saltiel announced the establishment of two new centers of collaboration within the multidisciplinary Life Sciences Institute (LSI) May 14 during LSI's Grand Opening Convocation.
Michael Jandernoa, a co-chair of The Michigan Difference campaign (left) chats with Alan Saltiel, director of the Life Sciences Institute (LSI), and Paul Meister of Fisher Scientific, a member of the LSI External Advisory Board, during an LSI grand opening event (above). Michael and Susan Jandernoa want to see young entrepreneurs have an impact in the world of life sciences and have established the Michael and Susan Jandernoa Life Sciences Initiative at the Business School, where Michael Jandernoa earned his bachelor’s degree. At right, visitors tour the LSI under a double-helix balloon display. (Photos by Martin Vloet, U-M Photo Services)
State Sen. Liz Brater (D-Ann Arbor), front, and others tour the Life Sciences Institute May 14. Tours of the building were part of the institute’s grand opening celebration, along with lectures and a concert by the Life Sciences Orchestra. (Photo by Martin Vloet, U-M Photo Services)

"Our recruiting is going well, and now is the time to begin initiatives that will really help to bring scientists together across scientific fields," Saltiel said. "These programs are at the forefront of scientific discovery and will catalyze interactions across the campus."

The Center for Chemical Genomics (CCG) will apply the latest high-throughput laboratory technology to the search for small molecular tools that will help researchers explore living cells.

These molecular tools will enable researchers to measure the cell's dynamic systems in action, relatively non-invasively. CCG tools may help discover how cells communicate, how they turn genes on and off, how they release newly made proteins, or send broken parts to the trash can.

The heart of CCG will be a robotic lab capable of screening tens of thousands of candidate molecules for possible effects on cells. This will be a core collaboratory for LSI scientists and other U-M researchers.

The center will be headed by David Sherman, the John Gideon Searle Professor of Medicinal Chemistry in the Department of Medicinal Chemistry (College of Pharmacy) and a research professor in LSI. Sherman's research centers on combing through naturally occurring chemicals from marine microorganisms to find potential cancer and anti-infective drugs.

The Center for Structural Biology is a critical mass of leading researchers shedding light on the very specific shapes and forms of molecules in the living cell and studying how they interact with one another in health and disease.

The collaboratory is centered around a protein production facility and an x-ray crystallography suite. This facility also serves as a core laboratory for all U-M researchers interested in understanding the three-dimensional structure of proteins.










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